The US NICEATM (NTP Interagency Center for the Evaluation of Alternative Toxicological Methods) held a workshop on AOPs: from Research to Regulation on 3-5th September 2014. The agenda and video casts of the plenary sessions are available online here.
An Adverse outcome pathways (AOP) describes causal Key Events (KEs) between a molecular initiating event (MIE) and an adverse outcome (AO). Events are linked by Key Event Relationships (KERs), which require a weight of evidence (WoE) assessment. AOPs may provide ways of presenting the weight of evidence for an effect, of identifying biomarkers and of identifying endpoints that require test development.