Monthly Archives: September 2014

AOP | what is an AOP?

An Adverse outcome pathways (AOP) describes causal Key Events (KEs) between a molecular initiating event (MIE) and an adverse outcome (AO). Events are linked by Key Event Relationships (KERs), which require a weight of evidence (WoE) assessment. AOPs may provide ways of presenting the weight of evidence for an effect, of identifying biomarkers and of identifying endpoints that require test development.

Continue reading